12/02/2021
Considerations to properly assess drug stability within biological samples
Assessing drug stability during method development and validation is of paramount importance. The concentration of the target analyte must remain unaffected throughout the lifecycle of the samples to ensure the reliability of the assay data. However, a decrease in analyte concentration in a biological fluid is not always due to a lack of stability.
In the work we present to the 14th EBF Open Symposium, we show several factors that can affect analyte concentration and that might lead to erroneous conclusions regarding its stability.
These misleading phenomena are described in the poster and focus on three main points:
• Non-specific adsorption.
• Equilibrium time between erythrocytes and plasma.
• Plasma age.
You may find below the poster for your ready reference:
MORE NEWS
The visit of the Mayor of Barcelona, Jaume Collboni, to Anapharm Bioanalytics
Last Friday, January 10th 2025, we had the honor of welcoming the Mayor of Barcelona, Jaume Collboni, to our facilities. His visit was a special opportunity for us to showcase the work we do at Anapharm Bioanalytics and to reaffirm our commitment to innovation in the field of bioanalysis.
Overcoming Matrix Effects in the Analysis of Lipophilic Compounds
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Overcoming Analytical Challenges in Liraglutide & Semaglutide Analysis
The work presented at the 10th EBF Young Scientist Symposium highlights the analytical challenges of developing UPLC/MS/MS methodologies for the extraction and quantification of Liraglutide and Semaglutide in plasma, while also outlining the strategies employed to solve them.